منابع مشابه
Mending a broken heart: the role of mitophagy in cardioprotection.
The heart is highly energy dependent with most of its energy provided by mitochondrial oxidative phosphorylation. Mitochondria also play a role in many other essential cellular processes including metabolite synthesis and calcium storage. Therefore, maintaining a functional population of mitochondria is critical for cardiac function. Efficient degradation and replacement of dysfunctional mitoch...
متن کاملMenDing a Broken Heart: steM Cells anD CarDiaC repair
Cardiovascular disease (CVD), which includes hypertension, coronary heart disease (CHD), stroke, and congestive heart failure (CHF), has ranked as the number one cause of death in the United States every year since 1900 except 1918, when the nation struggled with an influenza epidemic. In 2002, CVD claimed roughly as many lives as cancer, chronic lower respiratory diseases, accidents, diabetes ...
متن کاملMyocardin-related transcription factor-A: mending a broken heart.
Ventricular remodeling following myocardial infarction (MI) is a complex process driven by the response of both the myocytic and the nonmyocytic components of the heart to dynamic mechanical and neurohumoral stimuli. Despite the advent of reperfusion therapy and the administration of drugs slowing the progression of heart failure, many patients experiencing a MI undergo a progressive decline in...
متن کاملMending a Broken Heart: The Role of Sarcospan in Duchenne Muscular Dystrophy–Associated Cardiomyopathy
D uchenne muscular dystrophy (DMD) is the most severe and most common form of X-linked muscular diseases. It has been known for over 25 years that DMD is caused by a gene mutation leading to the near total absence of functional dystrophin protein. Transcription of the gene is controlled by 3 independent promoters of which the muscle (M) promoter drives high expression of dystrophin in skeletal ...
متن کاملBiomimicry in mending the broken heart; Will hypoxia and pulsatile flow play Cupids?
Oxygen, the most important cellular nutrition, is delivered through a pulsatile blood flow in vertebrates to the tissues and cells in vivo, wherein the oxygen concentration, its availability gradient between systolic and diastolic phase of cardiac activity differ between organs. In the in vitro conditions, manipulation of oxygen availability to the cells under culture have yielded varying behav...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 2003
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960261003